Although I have not done any comprehensive research into the spectrum of available charities, and so offer no informed endorsement or particular insight, my wife and I donated to the International Response Fund of the American Red Cross. I don't pretend to have any good formula for prioritizing world crises and needs, either, but this disaster seemed too catastrophic to ignore, and the needs too straightforward to second-guess.  

Peace, on this planet, is dangerous enough, and paradise fragile. Natural disasters ought to remind us how inexcusable it is to compound the difficulty of existing here by destroying our environment and undermining our cultures and inventing ideologies to justify wars.  

Do something good today.